{"product_id":"bioisosteres-in-medicinal-chemistry-9783527654321","title":"Bioisosteres in Medicinal Chemistry","description":"\u003cp\u003eWritten with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":53930852188439,"sku":null,"price":17670.12,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783527654321.jpg?v=1784111349","url":"https:\/\/payment.letskitaboo.com\/products\/bioisosteres-in-medicinal-chemistry-9783527654321","provider":"Kitaboo One eStore","version":"1.0","type":"link"}