{"product_id":"peptidomimetics-in-organic-and-medicinal-chemistry-9781118683149","title":"Peptidomimetics in Organic and Medicinal Chemistry","description":"\u003cp\u003eA peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":53864012382487,"sku":null,"price":15438.45,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/1601498.webp?v=1784058452","url":"https:\/\/payment.letskitaboo.com\/products\/peptidomimetics-in-organic-and-medicinal-chemistry-9781118683149","provider":"Kitaboo One eStore","version":"1.0","type":"link"}