{"product_id":"cancer-stem-cell-resistance-to-targeted-therapy-9783030166243","title":"Cancer Stem Cell Resistance to Targeted Therapy","description":"\u003cp\u003eThis book represents an up-dated summary of the state of the art of the characterization of cancer stem cell\/ cancer initiating cell (CSC\/CIC) properties.  An overview of the definition and biological properties of CSCs\/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs\/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs\/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs\/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs\/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52916383645975,"sku":null,"price":12080.49,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030166243.jpg?v=1781589744","url":"https:\/\/payment.letskitaboo.com\/te\/products\/cancer-stem-cell-resistance-to-targeted-therapy-9783030166243","provider":"Kitaboo One eStore","version":"1.0","type":"link"}