{"product_id":"palladium-and-nickel-catalyzed-transformations-forming-functionalized-heterocycles-9783030540777","title":"Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles","description":"\u003cp\u003eThis book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility.   Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52915028001047,"sku":null,"price":17479.59,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030540777.jpg?v=1781512927","url":"https:\/\/payment.letskitaboo.com\/te\/products\/palladium-and-nickel-catalyzed-transformations-forming-functionalized-heterocycles-9783030540777","provider":"Kitaboo One eStore","version":"1.0","type":"link"}