{"product_id":"total-synthesis-of-natural-products-with-antimicrobial-activity-9789811088063","title":"Total Synthesis of Natural Products with Antimicrobial Activity","description":"\u003cp\u003eThis thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":53645609894167,"sku":null,"price":13700.64,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9789811088063.jpg?v=1783504283","url":"https:\/\/payment.letskitaboo.com\/te\/products\/total-synthesis-of-natural-products-with-antimicrobial-activity-9789811088063","provider":"Kitaboo One eStore","version":"1.0","type":"link"}