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Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types.  The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers.  Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914850890007,"sku":null,"price":9447.07,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030388621.jpg?v=1781510762"},{"product_id":"cancer-the-enemy-from-within-9783030406516","title":"Cancer: The Enemy from Within","description":"\u003cp\u003eThis comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers.  Developed out of the renowned author’s many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world.  Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges thatlimit progress in cancer research.     A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914853576983,"sku":null,"price":9447.07,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030406516.jpg?v=1781510834"},{"product_id":"natural-products-for-cancer-chemoprevention-9783030398552","title":"Natural Products for Cancer Chemoprevention","description":"\u003cp\u003eThis book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914853708055,"sku":null,"price":17479.59,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030398552.jpg?v=1781510838"},{"product_id":"imaging-in-pediatric-oncology-9783030037772","title":"Imaging in Pediatric Oncology","description":"\u003cp\u003eThis book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914861768983,"sku":null,"price":14780.04,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030037772.jpg?v=1781511075"},{"product_id":"clinical-ophthalmic-oncology-9783030041137","title":"Clinical Ophthalmic Oncology","description":"\u003cp\u003eWritten by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors'' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations.  Clinical Ophthalmic Oncology''s clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. 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Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors'' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations.  Clinical Ophthalmic Oncology''s clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume provides the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors, carefully explained with treatment options considered in detail.​\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914868650263,"sku":null,"price":14780.04,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030060466.jpg?v=1781511264"},{"product_id":"pericyte-biology-in-different-organs-9783030110932","title":"Pericyte Biology in Different Organs","description":"\u003cp\u003eThe present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research.  This volume explores pericytes'' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells'' unique history. 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It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer,  these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. 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Successful collaboration and teamwork between pathology and clinical specialties (especially hematology\/oncology) are paramount for excellent patient care. In addition to diagnosis, pathology plays a significant role in lymphoma prognostication and therefore contributes to patient's management and follow-up. Lymph Node Pathology for Clinicians provides a concise overview of different entities in lymph node pathology with the primary audience being clinicians. Not all entities are covered, but, rather, the most common and\/or clinically most relevant ones were included. This text is intended as a quick reference for a clinician to become familiar with pathologic aspects of lymphomas and the thought process of a pathologist. Particular consideration is given to relevant diagnostic and prognostic ancillary studies. 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It presents the most up-to-date research and clinical practice from  leading specialists across a range of fields that come into contact with older breast cancer patients.   With new chapters on nursing and clinical trials in older women, as well as patient perspectives and the issues of managing patients with cognitive impairment, the book offers a new focus on this increasingly common and important group of patients. Multidisciplinary in its approach, this book covers all the bases for managing breast cancer in older women. The full range of therapeutic options is presented, as well as the epidemiology and specific psychosocial considerations for older patients.   Medical, surgical and radiation oncologists, breast nurses, gerontologists and all healthcare professionals involved in the management of older breast cancer patients will benefit from this unique and important work.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52914965807383,"sku":null,"price":14780.04,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030118754.jpg?v=1781511400"},{"product_id":"transanal-minimally-invasive-surgery-tamis-and-transanal-total-mesorectal-excision-tatme-9783030115722","title":"Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal Excision (taTME)","description":"\u003cp\u003e?This book captures cornerstone developments in a new body of knowledge and provides an expert resource on a \u0026amp;quote;hot topic\u0026amp;quote; in rectal surgery. Transanal minimally invasive surgery (TAMIS) was designed for local excision of select rectal neoplasms, however soon it became realized that the TAMIS technique could be used for applications beyond local excision, most notably for transanal total mesorectal excision (taTME).  This new operative technique has revolutionized our approach to the distal rectum by allowing for improved access, especially in obese male patients with an android pelvis, and by minimizing abdominal wall access trauma. The endpoints of improved oncologic resection, as defined by mesorectal envelope completeness, negative circumferential resection margins, and negative distal margin, are assessed.  This book details controversies, pitfalls, and future directions of taTME and TAMIS. 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With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the burden of immune-related adverse events will undoubtedly increase. Given these limitations and increase in health care costs associated with such therapies, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. This new edition will inform readers on the latest in biomarker development to identify patients who are more likely to respond, and strategies to overcome the challenges of immune-related adverse events. In addition, the authors recognize that including the missing patient voice in clinical trials and longitudinal assessment of symptom reports may help to identify early indicators of response or toxicity. Thus, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies. 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