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This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1.  While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. 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Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. 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The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. 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It also highlights the importance of cancer genomics, disease advancement, personalized medicine and psychological support for cancer patients. Emphasis is also given to the many challenges in the area of designing cancer treatment and designing clinical trials. The complete book also presents cancer management with different cancer treatment modalities, including pharmacogenomics and drug reactions. This is a unique and comprehensive piece of work that not only highlights the disease treatment modalities but also focuses on many challenges in the area of designing cancer treatment and even in designing clinical trials.The contributing authors are experts in this field of cancer treatment. By familiarizing readers with the latest developments in this complex field, the book offers a valuable resource for clinicians. 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This is an ideal guide for radiologists who want to enhance or initiate prostate MRI service for their referring clinicians and as a manual for technologists and those who are in training.   Prostate cancer is the second leading cause of cancer death in men, exceeded only by lung cancer. The best predictor of disease outcome lies with correct diagnosis, which requires precise imaging and diagnostic procedures aided by prostate MRI. Urologists, medical oncologists and radiation oncologists all agree that multi-parametric prostate MRI is essential for evaluation of prostate cancer.  However, the technical aspects of prostate MR imaging are not as straightforward as for the other imaging modalities and constantly evolving. Its small size presents a real challenge to the radiologist, who needs to do the T2 and diffusion weighted images and perform a dynamic contrast enhanced sequence correctly.  These images may also need to be analyzed on an independent workstation. Due to the absence of a current reference manual, when a radiologist wants to establish a prostate imaging service, he\/she needs to attend dedicated prostate MR workshops or dive into the literature search alone, only to get more confused about what to do and how to do it.With this book, expert authors were asked to give clear guidance to those who want to enhance or initiate their prostate imaging service. With this much-needed, concise, practical guidance, radiologists can perform and interpret multi-parametric prostate MRI in a standardized fashion, in concordance with PI-RADS v2.1 that can be applicable to all available hardware platforms (GE, Philips, Siemens, Toshiba). Additionally, they can perform post-processing for possible targeted biopsy and interpret post-therapy and PET studies. The book discusses imaging protocols (planning and prescription) and sequence parameters with representative images for each MRI sequence. This handbook-style practical manual can be used in the radiology reading room by those interpreting the MR exam as a reference as well as at the MRI scanner by the technologists as a guide. Coverage of basic prostate anatomy, pathology, Urologists point of view, MRI guided radiation treatment planning and molecular imaging is also included. 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Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52895069045015,"sku":null,"price":17479.59,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030357276.jpg?v=1781258727"},{"product_id":"nursing-adolescents-and-young-adults-with-cancer-9783319735559","title":"Nursing Adolescents and Young Adults with Cancer","description":"\u003cp\u003eThis book describes and explains how caring for adolescents and young adults with cancer (AYA) has developed into what is now a recognized and distinct field of nursing practice. 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Some books are available that describe AYA cancer care, service delivery and aspects of age appropriate care but this volume will be the first to focus on how nurses contribute to AYA cancer care in practice. 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In turn, the second addresses reconstructive breast surgery management. The authors present oncoplastic procedures for reconstructing the breast following small defects due to cancer or other conditions (BCT), as well as the use of microvascular free flaps, such as abdominal, thigh or gluteal-based flaps, for a complete reconstruction. Preventive reconstructive surgery and cutting-edge techniques, such as lipofilling or breast reconstruction together with lymph node transplantation, are also included. 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Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52911132344599,"sku":null,"price":29627.57,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030731199.jpg?v=1781260353"},{"product_id":"transsphenoidal-surgery-9783319566917","title":"Transsphenoidal Surgery","description":"\u003cp\u003eThis work details contemporary clinical knowledge on the multidisciplinary management of pituitary and other sellar\/parasellar tumors, with a focus on surgical techniques and a particular emphasis on complication avoidance and management. 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This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. 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This book provides concise, up-to-date information ranging from commonly-used dose-fractionation schemes for hypofractionated and stereotactic body radiotherapy to simulation and treatment specifications to published safety and efficacy data. Chapters additionally examine the biological rationales for the efficacy of hypofractionated radiation; present clinical studies that demonstrate the efficacy and safety of hypofractionated radiation treatment in a variety of cancers; and describe the advances in technology that have allowed hypofractionated radiation to be safely given. All chapters are fully revised with the latest treatments and updated effectiveness and toxicity of previously discussed treatments, all based on recent clinical trials and large analytical studies. 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