{"product_id":"springer-theses-9789813366138","title":"Springer Theses","description":"\u003cp\u003eThis book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely \u0026amp;quote;chiral center induced peptide helicity (CIH)\u0026amp;quote;. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers' understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":53590698885399,"sku":null,"price":18738.3,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9789813366138.jpg?v=1782739550","url":"https:\/\/payment.letskitaboo.com\/ur\/products\/springer-theses-9789813366138","provider":"Kitaboo One eStore","version":"1.0","type":"link"}