{"product_id":"tumor-suppressor-par-4-9783030735722","title":"Tumor Suppressor Par-4","description":"\u003cp\u003ePar-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.  Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical\/translational facets.\u003c\/p\u003e","brand":"Gardners","offers":[{"title":"Default Title","offer_id":52911185002775,"sku":null,"price":20179.14,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0679\/6918\/8119\/files\/9783030735722.jpg?v=1781262775","url":"https:\/\/payment.letskitaboo.com\/ur\/products\/tumor-suppressor-par-4-9783030735722","provider":"Kitaboo One eStore","version":"1.0","type":"link"}